Dilated Cardiomyopathy Due to BLC2-Associated Athanogene 3 (BAG3) Mutations

摘要

BackgroundThe BAG3 (BLC2-associated athanogene 3) gene codes for an antiapoptotic protein located on the sarcomere Z-disc. Mutations in BAG3 are associated with dilated cardiomyopathy (DCM), but only a small number of cases have been reported to date, and the natural history of BAG3 cardiomyopathy is poorly understood.