Novel SN38 derivative-based liposome as anticancer prodrug: an in vitro and in vivo study

摘要

BackgroundMany novel drug delivery systems have been extensively studied to exploit the full therapeutic potential of SN38, which is one of the most potent antitumor analogs of camptothecins (CPTs), whose clinical application is seriously hindered by poor water solubility, low plasmatic stability, and severe toxicity, but results are always unsatisfactory.