Cyclodepsipeptides and Other O-Containing Heterocyclic Metabolites from Beauveria felina EN-135 a Marine-Derived Entomopathogenic Fungus

摘要

Bioassay-guided fractionation of a culture extract of Beauveria felina EN-135, an entomopathogenic fungus isolated from a marine bryozoan, led to the isolation of a new cyclodepsipeptide, iso-isariin D (>1); two new O-containing heterocyclic compounds that we have named felinones A and B (>2 and >3); and four known cyclodepsipeptides (>4–>7). The structures were elucidated via spectroscopic analysis, and the absolute configurations of >1 and >2 were determined using single-crystal X-ray diffraction and CD, respectively. All isolated compounds were evaluated for antimicrobial activity and brine-shrimp (Artemia salina) lethality.