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Treg cells in the course of chronic hepatitis C virus infection partially normalize in longitudinal observation after successful DAA treatment regardless of hepatic fibrosis stage

机译：Treg细胞在慢性丙型肝炎病毒感染过程中无论肝纤维化阶段如何慢性丙型肝炎病毒感染在纵向观察中部分正常化

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摘要

Elevated circulating CD4+ CD25+ Foxp3+ regulatory T cells in patients with chronic hepatitis C (CHC) play an unspecified role in liver fibrosis development. This study aimed to determine whether Treg cells diminish after successful treatment with directacting antivirals (DAA) in patients at different liver fibrosis stages.

机译：慢性丙型肝炎患者（CHC）升高的循环CD4 + CD25 + Foxp3 +调节T细胞在肝纤维化发育中起未指明的作用。该研究旨在确定在不同肝纤维化阶段的患者中成功治疗后Treg细胞是否在成功治疗后递减。

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期刊名称 Clinical and Experimental Hepatology
作者
Agata Zientarska; Mariusz Kaczmarek; Iwona Mozer-Lisewska; Arleta Kowala-Piaskowska; Aleksandra Witkowska; Jan Żeromski;
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作者单位

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年(卷),期 2021(7),2
年度 2021
页码 196–204
总页数 9
原文格式 PDF
正文语种
中图分类外科学;
关键词

机译：丙型肝炎;肝纤维化;Treg细胞;

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专利

1. Management Of Patients With Hepatitis B Virus Reactivation Post–DAA Treatment Of Chronic Hepatitis C Virus Infection In HCV–HBV Coinfected Patients With Pretreatment HBeAg Seroconversion And Early Degree Of Hepatic Fibrosis [J] . Heba Ahmed Osman, Ali A Ghweil, Abeer MM Sabry, Infection and Drug Resistance . 2019,第6期

机译：DAA治疗后HCV–HBV合并感染的HBeAg血清转化和肝纤维化早期程度的慢性丙型肝炎病毒感染患者的治疗
2. Prospective assessment of the impact of successful DAAs treatment on liver fibrosis stage and predictors of fibrosis regression in patients with chronic hepatitis C and advanced fibrosis stage [J] . Davidov Yana, Kleinbaum Yeroham, Inbar Yael, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2017,第Suppla1期

机译：慢性丙型肝炎患者肝纤维化阶段肝纤维化阶段对肝纤维化阶段及预测性的预期评价
3. Fas-mediated hepatocyte apoptosis is increased by hepatitis C virus infection and alcohol consumption, and may be associated with hepatic fibrosis: mechanisms of liver cell injury in chronic hepatitis C virus infection. [J] . Pianko S igpond.net.au, Patella S, Ostapowicz G, Journal of viral hepatitis. . 2001,第6期

机译：Fas介导的肝细胞凋亡因丙型肝炎病毒感染和饮酒而增加，并且可能与肝纤维化有关：慢性丙型肝炎病毒感染中肝细胞损伤的机制。
4. Chronic Hepatitis and Primary Liver Cancer in Woodchucks (Marmota monax) associated with Chronic Woodchuck Hepatitis Virus (WHV) Infection [C] . Tennant B.C., Hornbuckle W.E., Bellezza C.A., Annual Meeting of the American Society for Veterinary Clinical Pathology . 2004

机译：慢性肝炎和原发性肝癌在啄木鸟（Marmota Monax）与慢性啄木枝肝炎病毒（WHV）感染相关
5. Viral Vaccine Vectors for the Treatment of Chronic Hepatitis B Virus Infection. [D] . Reynolds, Tracy Dawn. 2015

机译：用于治疗慢性乙型肝炎病毒感染的病毒疫苗载体。
6. Management Of Patients With Hepatitis B Virus Reactivation Post–DAA Treatment Of Chronic Hepatitis C Virus Infection In HCV–HBV Coinfected Patients With Pretreatment HBeAg Seroconversion And Early Degree Of Hepatic Fibrosis [O] . Heba Ahmed Osman, Ali A Ghweil, Abeer MM Sabry, 2019

机译：DAA治疗后HCV–HBV合并感染的HBeAg血清转化和肝纤维化早期程度的慢性丙型肝炎病毒感染患者的治疗
7. >Management Of Patients With Hepatitis B Virus Reactivation Post–DAA Treatment Of Chronic Hepatitis C Virus Infection In HCV–HBV Coinfected Patients With Pretreatment HBeAg Seroconversion And Early Degree Of Hepatic Fibrosis [O] . Heba Ahmed Osman, Ali A. Ghweil, Abeer M. M. Sabry, 2019

机译：>乙型肝炎病毒重新激活患者治疗慢性丙型肝炎病毒感染患者HCV-HBV兴奋剂治疗患者的预处理HBEAG血清转化和早期肝纤维化患者

Treg cells in the course of chronic hepatitis C virus infection partially normalize in longitudinal observation after successful DAA treatment regardless of hepatic fibrosis stage

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