Targeting androgen receptor (AR) with antiandrogen Enzalutamide increases prostate cancer cell invasion yet decreases bladder cancer cell invasion via differentially altering the AR/circRNA-ARC1/miR-125b-2-3p or miR-4736/PPARγ/MMP-9 signals

摘要

The qPCR analysis of circRNA-ARC1 (ARC1) in response to the knock down of AR in C4-2 and CWR22Rv1 cells (A), and in T24 and TCC-SUP cells (B). Effect of Enz treatment on expression of circRNA-ARC1 in PCa and BCa cell lines. The qPCR analysis of ARC1 expression after Enz treatment in CWR22Rv1 cell line (C) and in UMUC3 and T24 cells (D). RNase R-digestion assay to confirm circularity of ARC1 in C4-2 cells (E) and T24 cells (F). Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.