Improvement of antibiotics absorption and regulation of tissue oxygenation through blood laser irradiation

摘要

A point of this work is to estimate the impact of laser blood irradiation controlled intravenously at the level of an antibiotic. Hundred and twenty grown-up female adult rabbits were utilized in this investigation. They were separated into two equivalent groups relying upon the method for managing of the antibiotic. First group injected with10 mg/kg b. w of Moxifloxacin antibiotic while second group was given the Moxifloxacin but in a type of a tablet, containing 10 mg/kg.b.w orally. Following, each group was partitioned into four equivalent subgroups; control and treated with laser therapy at different time. Gallium-Arsenide (GaAs) laser device, utilized for treatment, in wavelength 904 nm, power of 5mW, its include a connector by optical fiber with fine cannula fixed at its end. Rabbits of laser subgroup; were treated by presenting needle of cannula into ear-marginal vein for 10, 20 and 30min. Blood samples have been collected from both groups after 1, 2, 3, 4, 5 and 6 h intervals after treatment and had transmitted for analysis via a high-pressure liquid chromatography to determine level of Moxifloxacin in blood. The after-effects’ revealed a regular increment in Moxifloxacin level (ng/ml) in two groups until 3 h followed with a rapid decline until the end of the experiment. Blood Irradiation through low-level laser enhances the concentration of Moxifloxacin in the serum whatsoever; was the rout of its performance, besides the irradiation help within quickened clearance of blood beginning the drug.