Pharmacokinetics of Hu-Pi-Cheng-Qi decoction administered via enema to rats with acute pancreatitis

摘要

To the Editor: Acute pancreatitis (AP) is a common digestive system disease without specialized treatment until recently. Gastrointestinal function plays essential role in AP treatment and could be restored with Da-Cheng-Qi decoction (DCQD) as evidenced by our previous clinical study.[1] Based on the formula composing principles and our clinical experience, according to the traditional Chinese medicine theory that the lung and the large intestine are internal and externally related, Huzhang and Gualoupi were added into DCQD to form a new formula named Hu-Pi-Cheng-Qi decoction (HPCQD) which could increase the effects of purging Fu-Organ and ventilating lung. Enema with HPCQD is effective against AP in clinical practice; however, the pharmacokinetic parameters of HPCQD after enema administration in AP is unclear. According to formula tissue pharmacology, prescription compatibility is based on its pharmacokinetics. Furthermore, the active ingredients types absorbed into the body and the metabolic process could be significantly affected by different compatibility.[2] Therefore, our purpose was to elucidate the pharmacokinetic parameters when HPCQD is absorbed into blood circulation through the rectum, the effective components and the distribution of HPCQD via enema administration on AP rats.