Myristoylated TMEM39AS41 a cell-permeable peptide causes lung cancer cell death

摘要

The TMEM39A gene with PKB substrate motif is upregulated in lung adenocarcinoma patients. a Human TMEM39A expression in different tumor types from the TCGA database. Adapted from cBioPortal: http://www.cbioportal.org/index.do. b Schematic illustration of TMEM39A protein and derived peptide sequence from its PKB-substrate motif. Under lined S indicates phosphorylated site. H indicates helical region, c ELISA-based in vitro kinase assay of TMEM39AS41 peptide (n = 4). The conjugated TMEM39AS41 peptide on 96 plate was incubated with lysate of A549 cells for 30 min. Schematic illustration of this assay (upper column)