Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss

摘要

ABR thresholds (a), ABR wave I latencies (b), and ABR wave I amplitudes (c) of the wild-type (WT) C57BL/6 mice at the age of 2, 5, and 12 months (n = 6 for 2-month-old mice, n = 3 for 5-month-old mice, and n = 6 for 12-month-old mice). The data represent the mean ± SEM. *P < 0.05, **P < 0.01. Two-way analysis of variance (ANOVA) followed by Tukey’s multiple comparison test was applied. As the ABR wave I latencies and amplitudes that were induced by a stimulus intensity of 100 dB SPL were measured, one and two 12-month-old mice that exhibited ABR thresholds above 100 dB SPL at 4 and 32 kHz, respectively, were omitted from the waveform analysis shown in b and c.