Simple FISH-based evaluation of spermatic nuclear architecture shows an abnormal chromosomal organization in balanced chromosomal rearrangement carriers

摘要

a Chromosomal conformation in sperm nuclei. Chromosomes are bent at their centromeres, with their telomeres covalently linked to each other and to the nuclear membrane, with their centromeres gathered at the center, forming a structure called chromocenter. b Chromosomal territories in the super nuclei follow a non-random organization from Zalensky et al. (2007)