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LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay

机译：LC-MS / MS估计人肝微粒体中抗癌剂甘蛋白水平：代谢稳定性评估测定

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摘要

Tandutinib (MLN518 or CT 53518) (TND) is a novel, oral, small-molecule inhibitor of type III receptor tyrosine kinases utilized for the treatment of acute myeloid leukemia (AML).

机译：Tandutinib（MLN518或CT 53518）（TND）是一种用于治疗急性髓性白血病（AML）的III型受体酪氨酸激酶的新颖，口服，小分子抑制剂。

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期刊名称 Drug Design Development and Therapy
作者
Mohamed W Attwa; Ali S Abdelhameed; Nasser S Al-Shakliah; Adnan A Kadi;
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作者单位

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年(卷),期 2020(-1),-1
年度 2020
页码 -1
总页数 11
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词

机译：Tandutinib;代谢稳定性评估;体外半衰期;验证的LC-MS / MS方法;

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专利

1. Evaluation of cytochrome P450 inhibition assays using human liver microsomes by a cassette analysis /LC-MS/MS. [J] . Zambon S, Fontana S, Kajbaf M Drug metabolism letters . 2010,第3期

机译：用盒分析/ LC-MS / MS评价使用人肝微粒体的细胞色素P450抑制测定。
2. A sensitive and high-throughput LC-MS/MS method for inhibition assay of seven major cytochrome P450s in human liver microsomes using an in vitro cocktail of probe substrates [J] . Liu Li-Ya, Han Yong-Long, Zhu Jin-Hui, Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2015,第3期

机译：一种灵敏且高通量的LC-MS / MS方法，使用体外探针底物混合物抑制人肝微粒体中的7种主要细胞色素P450
3. Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis. [J] . Yao M, Zhu M, Sinz MW, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2007,第1期

机译：使用自动96孔微孔板孵育格式和LC-MS / MS分析，开发并全面验证了对人肝微粒体中5种主要细胞色素P450酶的6种抑制测定。
4. EVALUATION OF THE METABOLIC PROFILE OF 2-METHIOPROPAMINE BY LC-MS/MS IN MICE AND IN HUMAN LIVER MICROSOMES [C] . Cristian Camuto, Sheila Pellegrini, Monica Mazzarino, International Mass Spectrometry Conference . 2018

机译：用小鼠LC-MS / MS和人肝微粒体对2-甲基丙胺的代谢谱评价
5. Determination of Absolute Protein Content of Hepatic CYP4F Enzymes in Human Liver Microsomes Using LC/MS/MS Methodology and Comparison with Immunoquantification and Enzyme Activity. [D] . Michaels, Scott A. 2013

机译：使用LC / MS / MS方法测定人肝微粒体中肝CYP4F酶的绝对蛋白质含量，并与免疫定量和酶活性进行比较。
6. Development and validation of an HPLC–MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study [O] . Haitham Alrabiah, Adnan A. Kadi, Mohamed W. Attwa, 2018

机译：HPLC-MS / MS方法的开发和验证用于测定人血浆和大鼠肝微粒体中的精氨酸-加压素受体阻滞剂康尼普坦：在代谢稳定性研究中的应用
7. >LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay [O] . Mohamed W Attwa, Ali S Abdelhameed, Nasser S Al-Shakliah, 2020

机译：> LC-MS / MS估计人肝微粒体中抗癌剂的抗蛋白质水平：代谢稳定性评估测定

LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay

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