Searching for Possible Links between Alzheimer’s Disease and Systemic Sclerosis

摘要

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterised progressive cognitive and functional decline. The prevalence of AD ranges from 4.3% to 11.3% in European elderly populations over 65 years of age.1,2 Although degenerative processes in the blood-barrier protected brain neurons have long be considered as dominant in the pathophysiology of AD, mounting evidence especially from genetic studies including ours,3–5 and functional studies have identified immune system cells as critical players in initiation, maintenance or resolution of these processes.