Burying Our Heads in the Sand: The Neglected Importance of Reporting Inter-Rater Reliability in Antipsychotic Medication Trials

摘要

The declining efficacy of antipsychotic medication in randomized clinical trials has led to major concern. Over the last decade, the number of failed phase II trials raised by 15%. In the search for the causes of the apparent declining potency of antipsychotic medication, it has been suggested that the explanation may be found in inadequate rating procedures.1