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Superabsorbent poly(acrylic acid) and antioxidant poly(ester amide) hybrid hydrogel for enhanced wound healing

机译:超吸收剂聚(丙烯酸)和抗氧化聚(酯酰胺)杂交水凝胶用于增强伤口愈合

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摘要

Wound healing dressing is increasingly needed in clinical owing to the large quantity of skin damage annually. Excessive reactive oxygen species (ROS) produced through internal or external environmental influences can lead to lipid peroxidation, protein denaturation, and even DNA damage, and ultimately have harmful effects on cells. Aiming to sufficiently contact with the wound microenvironment and scavenge ROS, superabsorbent poly (acrylic acid) and antioxidant poly (ester amide) (PAA/PEA) hybrid hydrogel has been developed to enhance wound healing. The physical and chemical properties of hybrid hydrogels were studied by Fourier-transform infrared (FTIR) absorption spectrum, compression, swelling, degradation, etc. Besides, the antioxidant properties of hybrid hydrogels can be investigated through the free radical scavenging experiment, and corresponding antioxidant indicators have been tested at the cellular level. Hybrid hydrogel scaffolds supported the proliferation of human umbilical vein endothelial cells and fibroblasts, as well as accelerated angiogenesis and skin regeneration in wounds. The healing properties of wounds in vivo were further assessed on mouse skin wounds. Results showed that PAA/PEA hybrid hydrogel scaffolds significantly accelerated the wound healing process through enhancing granulation formation and re-epithelialization. In summary, these superabsorbent and antioxidative hybrid hydrogels could be served as an excellent wound dressing for full-thickness wound healing.
机译:由于每年的大量皮肤伤害,临床越来越需要伤口愈合敷料。通过内部或外部环境影响产生的过量的反应性氧(ROS)可以导致脂质过氧化,蛋白质变性,甚至DNA损伤,并最终对细胞产生有害影响。旨在充分接触缠绕的微环境和清除ROS,超吸收聚(丙烯酸)和抗氧化剂聚(酯酰胺)(PAA / PEA)杂交水凝胶以增强伤口愈合。通过傅立叶变换红外(FTIR)吸收光谱,压缩,溶胀,降解等研究了杂种水凝胶的物理和化学性质。此外,可以通过自由基清除实验和相应的抗氧化剂研究杂种水凝胶的抗氧化性能指标已在细胞水平进行测试。杂交水凝胶支架支持人脐静脉内皮细胞和成纤维细胞的增殖,以及加速血管生成和伤口的皮肤再生。在小鼠皮肤伤口中进一步评估体内伤口的愈合特性。结果表明,通过增强造粒形成和再上皮化,Paa /豌豆杂交水凝胶支架显着加速了伤口愈合过程。总之,这些超吸收性和抗氧化杂交水凝胶可以作为优异的伤口敷料,用于全厚伤口愈合。

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