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Biodegradable metals for bone fracture repair in animal models: a systematic review

机译:动物模型中骨折修复的可生物降解金属:系统评价

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摘要

Biodegradable metals hold promises for bone fracture repair. Their clinical translation requires pre-clinical evaluations including animal studies, which demonstrate the safety and performance of such materials prior to clinical trials. This evidence-based study investigates and analyzes the performance of bone fractures repair as well as degradation properties of biodegradable metals in animal models. Data were carefully collected after identification of population, interventions, comparisons, outcomes and study design, as well as inclusion criteria combining biodegradable metals and animal study. Twelve publications on pure Mg, Mg alloys and Zn alloys were finally included and reviewed after extraction from a collected database of 2122 publications. Compared to controls of traditional non-degradable metals or resorbable polymers, biodegradable metals showed mixed or contradictory outcomes of fracture repair and degradation in animal models. Although quantitative meta-analysis cannot be conducted because of the data heterogeneity, this systematic review revealed that the quality of evidence for biodegradable metals to repair bone fractures in animal models is ‘very low’. Recommendations to standardize the animal studies of biodegradable metals were proposed. Evidence-based biomaterials research could help to both identify reliable scientific evidence and ensure future clinical translation of biodegradable metals for bone fracture repair.
机译:可生物降解的金属持有骨折修复的承诺。他们的临床翻译需要临床前评估,包括动物研究,这证明了在临床试验之前这些材料的安全性和性能。该基于循证的研究调查和分析了动物模型中可生物降解金属的降解性能的性能。在识别人口,干预,比较,结果和研究设计后仔细收集数据,以及结合可生物降解金属和动物研究的纳入标准。最终包括在纯Mg,Mg合金和Zn合金上的12种出版物,并从收集的2122个出版物的数据库中提取后进行审查。与传统的不可降解金属或可再吸收性聚合物的对照相比,可生物降解的金属显示出骨折修复和动物模型降解的混合或矛盾的结果。虽然由于数据异质性无法进行定量的荟萃分析,但这种系统审查表明,可生物降解金属的证据质量是在动物模型中修复骨折的骨折是“非常低”。提出了标准化可生物降解金属的动物研究的建议。基于循证的生物材料研究可以帮助既可识别可靠的科学证据,并确保未来骨折修复可生物降解金属的临床翻译。

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