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The Prevalence of Ureaplasma Urealyticum and Mycoplasma Hominis Infections in Infertile Patients in the Northeast Region of Romania

机译:罗马尼亚东北地区不育患者脲基脲素和支原体Hominis感染的患病率

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摘要

Background and objectives: Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) are two commensal microorganisms that form the urogenital microbiota. Under a state of dysbiosis, both bacteria cause intrauterine infection. Material and methods: Therefore, the purpose of the present study was to analyze the prevalence of UU and MH among four hundred and eleven infertile women. Results: Women between thirty and thirty-five years old were the most affected group, followed by those that were 25 and 30 years old, respectively. Cumulatively, the prevalence of single UU and MH, and coinfection, was 28.46% (n = 117), (n = 2) 0.48%, and 2.91% (n = 12), respectively, with an overall detection rate of 31.87% (n = 131). To assess the associated drug susceptibility, endocervical samples were unequally sent to Regina Maria (n = 281) and Synevo (n = 130) laboratories for further analyses. Pristinamycin (100% vs. 100%) and Josamycin (100% vs. 98.00%) were the most efficient antibiotics in eradicating UU and MH, several others also displaying a high efficiency, among which can be mentioned Doxycycline (98.23%), Minocycline (96.00%), Tetracycline (96.48% vs. 68.00%), and Erythromycin (70.17% vs. 92.00%). Based on antibiograms, Clarithromycin (88.00%), Roxithromycin (88.00%), Levofloxacin (82.00%), and Azithromycin (78.94%) can be further used in treating such infections. On the other hand, Clindamycin (4.00%) and Ciprofloxacin (12.27% vs. 2.00%) are no longer viable because both UU and MH display an intermediate response towards gained resistance. Interestingly, the efficiency of Ofloxacin (22.79% vs. 60.00%) was conflicting, this possibly suggesting a transient stage to a gradual adaptability of these microorganisms to Ofloxacin. Conclusions: The most susceptible age groups in each case were women that were between twenty and forty years old. It can be concluded that four antibiotics can be safely used for treating UU, MH, or dual infections whose efficiency was over 95%.
机译:背景和目标:脲基脲素(UU)和支原体Hominis(MH)是形成泌尿生殖器微生物的共生微生物。在消化不良状态下,两种细菌都会导致宫内感染。材料和方法:因此,本研究的目的是分析uu和mh的患病率,四百份不孕妇女。结果:三十至三十五岁的女性是受影响最大的群体,其次分别为25岁及30岁。累积地,单一UU和MH的患病率和辛纤维分别为28.46%(n = 117),(n = 2)0.48%和2.91%(n = 12),总检测率为31.87%( n = 131)。为了评估相关的药物敏感性,内膜栖样品无比地送到Regina Maria(n = 281)和Synevo(n = 130)实验室,以进一步分析。普里替尼霉素(100%vs.100%)和josamycin(100%vs.98.00%)是根除UU和MH中最有效的抗生素,其他几种也显示出高效率,其中可以提及十氧环(98.23%),米诺环素(96.00%),四环素(96.48%vs.68.00%)和红霉素(70.17%vs.92.00%)。基于抗性曲线,克拉霉素(88.00%),Roxthromycin(88.00%),左氧氟沙星(82.00%)和二十霉素(78.94%)可以进一步用于治疗此类感染。另一方面,Clindamycin(4.00%)和环丙沙星(12.27%与2.00%)不再可行,因为UU和MH都显示出朝向耐受性的中间反应。有趣的是,氧氟沙星的效率(22.79%对60.00%)遭到矛盾,这可能表明瞬态阶段对这些微生物对氧氟沙星的逐渐适应性。结论:每种情况中最易感的年龄群是二十四十岁之间的女性。可以得出结论,可以安全地使用四种抗生素来治疗UU,MH或双重感染,其效率超过95%。

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