Development of an Insecticide-Free Trapping Bednet to Control Mosquitoes and Manage Resistance in Malaria Vector Control: A New Way of Thinking

摘要

Insecticide resistance in mosquitoes reduces the effectiveness of malaria control interventions and has reversed the gains made in reducing malaria morbidity. Hence, new strategies are needed to mitigate the spread of resistance, preserve the efficacy of available insecticides, and restore the effectiveness of control. To combat resistance to insecticides in malaria mosquitoes, WHO recommends using long-lasting insecticide-impregnated mosquito bednets (LLINs) as well as the synergist piperonyl-butoxide (PBO). PBO enhances the insecticidal effect of the treated bednet. Unfortunately, decreases in performance of PBO-LLINs are now reported in some regions of Africa where mosquitoes are resistant to insecticides. Our objective was to develop an insecticide-free, mechanical solution that kills mosquitoes regardless of their insecticide resistance status, ultimately overcoming the problem of insecticide resistance. We designed and developed an insecticide-free mosquito trapping bednet for mass mosquito trapping and killing, the “T-Net”, and we show its efficacy compared to a conventional LLIN in Africa. Mathematical models were also developed to predict T-Net efficacy in individual homes and at the community level.