Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer

摘要

a Waterfall plot of the ranked 6014 master regulators identified in the CRC cohort (n = 68) by metaVIPER algorithm. b Heatmap of correlation coefficients between estimated protein activities of BCL-XL, BCL-2, and MCL-1 across the CRC cohort (n = 68). c–e Ranking of tumor entities across the NCT/DKTK MASTER cohort (n = 1521) according to the estimated median protein activity of BCL-XL (c), BCL-2 (d), and MCL-1 (e) obtained by metaVIPER algorithm. f Arc diagram of the regulatory network of BCL-XL and BCL-2. The edges and nodes were color-coded according the direction of regulation and weighted according the average expression or protein activity in the CRC subset of the NCT/DKTK MASTER cohort.