Metabolic Profiling of Plasma in Different Calving Body Condition Score Cows Using an Untargeted Liquid Chromatography-Mass Spectrometry Metabolomics Approach

摘要

Over-conditioning around calving predisposes cows to a higher risk of postpartum metabolic disorders and diseases. Using untargeted liquid chromatography-mass spectrometry, seven metabolites were found that were significantly correlated to high body condition, as well as to classic metabolic parameters indicating changes in lipid metabolism and inflammation. These seven metabolites include six distinct lysophosphatidylcholines and a phosphatidylethanolamine. By investigating the depth of metabolic changes in the plasma of over-conditioned fresh cows, this study may provide a metabolic basis for the diseases associated with over-conditioning.