The circEPSTI1/mir-942-5p/LTBP2 axis regulates the progression of OSCC in the background of OSF via EMT and the PI3K/Akt/mTOR pathway

摘要

Expression profile of circRNAs in three paired OSCC and matched OSF tissues as well as in three NBM tissues. Six consistently deregulated circRNAs in tissue samples ( ) and OSCC cell lines ( ). RNase R exonuclease and actinomycin D assays confirmed the circular structure of circEPSTI1. The subcellular distribution of circEPSTI1 was cytoplasmic, as shown by FISH (scale bar 10 μm). The expression level of circEPSTI1 in 154 OSCC and matched OSF tissues was analyzed by RT-qPCR. ROC curve analysis revealed that circEPSTI1 could sensitively discriminate OSCC from OSF and OSF from NBM. Kaplan–Meier analysis of the correlation between circEPSTI1 expression and OS as well as PFS. ***  P P