Prospective cross‐sectional study using Poisson renewal theory to study phase singularity formation and destruction rates in atrial fibrillation (RENEWAL‐AF): Study design

摘要

Unstable functional reentrant circuits known as rotors have been consistently observed in atrial fibrillation and are mechanistically believed critical to the maintenance of the arrhythmia. Recently, using a Poisson renewal theory‐based quantitative framework, we have demonstrated that rotor formation (λ ) and destruction rates (λ ) can be measured using in vivo electrophysiologic data. However, the association of λ and λ with clinical, electrical, and structural markers of atrial fibrillation phenotype is unknown.