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Enhancement of BMP-2 and VEGF carried by mineralized collagen for mandibular bone regeneration

机译:用矿化胶原蛋白携带的BMP-2和VEGF进行下颌骨再生

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摘要

Repairing damage in the craniofacial skeleton is challenging. Craniofacial bones require intramembranous ossification to generate tissue-engineered bone grafts via angiogenesis and osteogenesis. Here, we designed a mineralized collagen delivery system for BMP-2 and vascular endothelial growth factor (VEGF) for implantation into animal models of mandibular defects. BMP-2/VEGF were mixed with mineralized collagen which was implanted into the rabbit mandibular. Animals were divided into (i) controls with no growth factors; (ii) BMP-2 alone; or (iii) BMP-2 and VEGF combined. CT and hisomputed tomography and histological staining were performed to assess bone repair. New bone formation was higher in BMP-2 and BMP-2-VEGF groups in which angiogenesis and osteogenesis were enhanced. This highlights the use of mineralized collagen with BMP-2/VEGF as an effective alternative for bone regeneration.
机译:修复颅面骨骼的损坏是挑战性的。颅面骨骼需要血管内骨化通过血管生成和骨质发生产生组织工程骨移植物。在这里,我们设计了一种用于BMP-2和血管内皮生长因子(VEGF)的矿化胶原蛋白递送系统,用于植入下颌缺陷的动物模型。将BMP-2 / VEGF与矿化胶原混合,该胶原植入兔下颌骨。将动物分为(I)对照,没有生长因子; (ii)单独的BMP-2;或(iii)BMP-2和VEGF组合。进行CT和Hothomuted断层扫描和组织学染色以评估骨骼修复。 BMP-2和BMP-2-VEGF组的新骨形成较高,其中增强了血管生成和骨质发生。这突出了用BMP-2 / VEGF使用矿化胶原蛋白作为骨再生的有效替代方案。

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