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Investigating materials and orientation parameters for the creation of a 3D musculoskeletal interface co-culture model

机译:研究3D肌肉骨骼界面共同培养模型的创建材料和方向参数

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摘要

Musculoskeletal tissue interfaces are a common site of injury in the young, active populations. In particular, the interface between the musculoskeletal tissues of tendon and bone is often injured and to date, no single treatment has been able to restore the form and function of damaged tissue at the bone–tendon interface. Tissue engineering and regeneration hold great promise for the manufacture of bespoke models or implants to be used to advance repair and so this study investigated the material, orientation and culture choices for manufacturing a reproducible 3D model of a musculoskeletal interface between tendon and bone cell populations. Such models are essential for future studies focussing on the regeneration of musculoskeletal interfaces . Cell-encapsulated fibrin hydrogels, arranged in a horizontal orientation though a simple moulding procedure, were shown to best support cellular growth and migration of cells to form an tendon–bone interface. This study highlights the importance of acknowledging the material and technical challenges in establishing co-cultures and suggests a reproducible methodology to form 3D co-cultures between tendon and bone, or other musculoskeletal cell types,
机译:肌肉骨骼组织界面是年轻,积极群体的常见伤害遗址。特别地,肌腱和骨骼的肌肉骨骼组织之间的界面通常受到损伤并且迄今为止,没有单一处理能够恢复骨骼衔接界面处受损组织的形式和功能。组织工程和再生能够对用于推进修复的定制模型或植入物的制造具有巨大的希望,因此本研究调查了用于制造肌腱和骨细胞群之间的肌肉骨骼界面的可再现3D模型的材料,取向和培养选择。这种模型对于未来的研究侧重于肌肉骨骼界面的再生的研究至关重要。沿水平取向布置的细胞包封纤维蛋白水凝胶,尽管是简单的模塑过程,以最佳支持细胞生长和细胞迁移形成肌腱骨界面。本研究强调了承认建立共同培养物的材料和技术挑战的重要性,并表明一种可重复的方法来形成肌腱和骨骼之间的3D共培养物,或其他肌肉骨骼细胞类型,

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