Attenuated live vaccine usage affects accurate measures of virus diversity and mutation rates in avian coronavirus infectious bronchitis virus

摘要

► Positive selection was not observed for IBV types where live vaccines are used. ► Positive selection was observed for IBV types where no vaccines exist. ► Seven recombination breakpoints sere observed distributed across the genome. ► Viruses within the same serotype can have a high degree of diversity outside of spike.