Chemotherapeutic Potential of Carthamus Oxycantha Root Extract as Antidiarrheal and In Vitro Antibacterial Activities

摘要

Our research work was designed to investigate the curative and preventive effects of root extract against diarrhea and microorganisms. For the antibacterial experiment, the agar well diffusion method was used against standard bacteria , , and while for the assessment of antidiarrheal activity, castor oil and the magnesium sulfate-induced diarrhea method was used on albino, laboratory-bred (BALB/c) mice at a dose rate of 200 and 400 mg/kg (body weight, b.w) orally. The methanol extract of significantly ( < 0.001) decreased the frequency of defecation, and wet stools in a dose depended on the manner of after receiving magnesium sulfate (2 g/kg (b.w)) and castor oil (1.0 mL/mice). Furthermore, the extract of showed concentration-dependent antimicrobial properties against followed by , and bacterial strains, with inhibitions ranging from 10.5–15 mm. These findings show significant results that is effective as an antidiarrheal and antibacterial agent. However, further works are needed to establish its mode of action.