17. THE OPTiMISE STUDY: AMISULPRIDE AND OLANZAPINE FOLLOWED BY OPEN-LABEL TREATMENT WITH CLOZAPINE IN FIRST-EPISODE SCHIZOPHRENIA

摘要

No accepted treatment algorithm exists for patients with first episode schizophrenia. Whether switching antipsychotics, how long to wait for a response, or if early use of clozapine improves out-come in first-episode schizophrenia is unknown. The OPTiMISE study assessed 481 first episode schizophrenia patients using three phase switching study. Patients with a first episode of schizophrenia entered a four-week open treatment with amisulpride. Those patients who did not achieved remission entered a 6-week, randomized, double-blind study of either continuation of amisulpride or switching to olanzapine. Those patients who still not achieved remission were treated with clozapine for 12-weeks in an open study design.