Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) drives migration and progression of T-cell acute lymphoblastic leukemia in vitro and in vivo

摘要

Microarray expression analysis of comparing bone marrow samples from healthy donors (  = 72) and T-ALL patients (  = 174), ***  = 6.8e−10. Analysis of comparing PRL-3 expression between bone marrow samples from T-ALL patients achieving remission and patients with induction failure. NS = not significant. Representative western blot analysis of ( ) primary patient T-ALL and PBMCs, and ( ) human T-ALL cell lines, showing PRL-3 expression. The total protein loaded in each sample was used as loading control instead of housekeeping protein, with a band of ~50 kD chosen as a representative image in the figure.