Big Challenge in Big Data Research: Continual Dispute on Big Data Analysis

摘要

More than 2/3 of patients with hypertension need drugs from more than 2 drug classes with different mechanisms to achieve control of hypertension. Combination therapy is particularly helpful for patients receiving prolonged blood pressure treatment, and high-risk patients. Because recent hypertension guidelines recommends more intensive blood pressure control, most hypertensive patients require drug combination. Combination therapy is more effective than single-drug therapy at a higher dose. Therefore 2018 European Society of Cardiology (ESC)/European Society of Hypertension (ESH) guideline even recommends dual combination treatment as initial therapy in most hypertensive patients rather than monotherapy.