RbAp48 expression and neuronal damage in the gerbil hippocampus following 5 min of transient ischemia

摘要

RbAp48 immunohistochemistry in CA1 of the sham operated ( ) and ischemia operated ( - ) gerbils. In the sham operated gerbils, strong RbAp48 immunoreactivity is shown in pyramidal cells (thick arrows) and non-pyramidal cells (thin arrows). RbAp48 immunoreactivity is decreased in pyramidal cells at 2 days post-ischemia. At 5 days and 10 days post-ischemia, RbAp48 immunoreactive pyramidal cells (asterisks) were few; however, RbAp48 immunoreactive non-pyramidal cells (thin arrows) are significantly increased in numbers. SO, stratum oriens; SP, stratum pyramidale; SR, stratum radiatum. Scale bar = 50 μm. (F, G) ROD as % of RbAp48 immunoreactive structures in the SP ( ), and in the SO and SR ( ) after transient ischemia (  = 7 at each point in time,  †