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A Renal Impairment Subgroup Analysis of the Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy

机译：纳德定治疗阿片类药物引起的慢性非癌性疼痛患者安全性和有效性的肾损伤亚组分析

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摘要

Naldemedine, an oral, peripherally acting μ-opioid receptor antagonist approved for the treatment of opioid-induced constipation (OIC), is renally excreted. This subgroup analysis integrated data from 3 Phase 3 trials (COMPOSE-1, COMPOSE-2, COMPOSE-3) to evaluate the safety and efficacy of naldemedine in patients with renal impairment (RI).

机译：Naldemedine是一种经批准可用于治疗阿片类药物引起的便秘（OIC）的口服，作用于周围的μ阿片类药物受体拮抗剂，可从肾脏排泄。该亚组分析综合了3项3期试验（COMPOSE-1，COMPOSE-2，COMPOSE-3）的数据，以评估纳洛酮在肾功能不全（RI）患者中的安全性和有效性。

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期刊名称 Journal of Pain Research
作者
Lynn R Webster; Martin E Hale; Tadaaki Yamada; James E Wild;
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作者单位

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年(卷),期 2020(13),-1
年度 2020
页码 -1
总页数 8
原文格式 PDF
正文语种
中图分类基础医学;
关键词
opioid-related disorders; opioid analgesics; naldemedine; renal insufficiency; constipation; chemically induced;

机译：阿片相关疾病;阿片类镇痛药;纳地定;肾功能不全;便秘;化学诱导;

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1. A Renal Impairment Subgroup Analysis of the Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy [J] . Lynn R Webster, Martin E Hale, Tadaaki Yamada, Journal of Pain Research . 2020,第1期

机译：肾脏损伤亚组分析纳尔德梅汀治疗慢性非癌症疼痛接受阿片类药物治疗患者阿片类药物诱导的便秘的疗效分析
2. Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy: A Subgroup Analysis of Patients >= 65 Years of Age [J] . Wild James, Webster Lynn, Yamada Tadaaki, Drugs and aging . 2020,第4期

机译：Naldemedine治疗慢性非癌症疼痛患者阿片类药物诱导的便秘的安全性和有效性：患者的亚组分析> = 65岁
3. A Phase 2b, Randomized, Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain [J] . Webster Lynn R., Yamada Tadaaki, Ferreira Juan Camilo Arjona Pain medicine : . 2017,第12期

机译：第2B期，随机双盲安慰剂对照研究，以评估Naldemedine用于治疗慢性非癌症疼痛患者阿片类药物诱导的便秘的疗效和安全性
4. Study of Efficacy and Safety of Willow Bark Extract (Assalix) in Treatment of Chronic Low Back Pain in Patients of Different Age with Osteochondrosis [C] . V.V. Povoroznyuk, T.A. Karasevskaya International Pain Clinic Congress . 2008

机译：柳树皮提取物（Assalix）治疗不同年龄患者慢性低腰疼痛的疗效和安全性研究
5. The influence of pain self-management education on the prevalence of opioid prescription among patients with chronic non-cancer pain: An agent-based modeling simulation. [D] . Samuel-Ojo, Catherine O. 2015

机译：疼痛自我管理教育对慢性非癌性疼痛患者中阿片类药物处方的影响：基于代理的建模仿真。
6. A Phase 2b Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain [O] . Lynn R Webster, Tadaaki Yamada, Juan Camilo Arjona Ferreira -1

机译：2b期随机双盲安慰剂对照研究用于评价纳尔定汀治疗阿片类药物引起的慢性非癌性疼痛患者的有效性和安全性
7. Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy: A Subgroup Analysis of Patients ≥ 65 Years of Age [O] . James Wild, Lynn Webster, Tadaaki Yamada, 2020

机译：Naldemedine治疗阿片类药物治疗慢性非癌症疼痛患者的患者的安全性和有效性：患者≥65岁的患者亚组分析

A Renal Impairment Subgroup Analysis of the Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy

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