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In search of stool donors: a multicenter study of prior knowledge perceptions motivators and deterrents among potential donors for fecal microbiota transplantation

机译:寻找粪便供体:对粪便微生物群移植潜在供体之间的先验知识观念动机和威慑因素的多中心研究

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摘要

Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridioides difficile infection. Stool donors are essential, but difficult to recruit and retain. We aimed to identify factors influencing willingness to donate stool. This multi-center study with a 32-item questionnaire targeted young adults and health care workers via social media and university email lists in Edmonton and Kingston, Canada; London and Nottingham, England; and Indianapolis and Boston, USA. Items included baseline demographics and FMT knowledge and perception. Investigated motivators and deterrents included economic compensation, screening process, time commitment, and stool donation logistics. Logistic regression and linear regression models estimated associations of study variables with self-assessed willingness to donate stool. 802 respondents completed our questionnaire: 387 (48.3%) age 21-30 years, 573 (71.4%) female, 323 (40%) health care workers. Country of residence, age and occupation were not associated with willingness to donate stool. Factors increasing willingness to donate were: already a blood donor (OR 1.64), male, altruism, economic benefit, knowledge of how FMT can help patients (OR 1.32), and positive attitudes towards FMT (OR 1.39). Factors decreasing willingness to donate were: stool collection unpleasant (OR 0.92), screening process invasive (OR 0.92), higher stool donation frequency, negative social perception of stool, and logistics of collection/transporting feces. We conclude that 1) blood donors and males are more willing to consider stool donation; 2) altruism, economic compensation, and positive feedback are motivators; and 3) screening process, high donation frequency, logistics of collection/transporting feces, lack of public awareness, and negative social perception are deterrents. Considering these variables could maximize donor recruitment and retention.
机译:粪便微生物菌群移植(FMT)是复发性艰难梭菌感染的高效治疗方法。粪便捐赠者是必不可少的,但很难招募和保留。我们旨在确定影响大便捐赠意愿的因素。这项包含32项问卷的多中心研究通过社交媒体和加拿大埃德蒙顿和金斯敦的大学电子邮件列表,针对年轻人和医疗保健工作者;伦敦和英国诺丁汉;以及印第安纳波利斯和美国波士顿。项目包括基线人口统计资料和FMT知识和认知。调查的动机和威慑因素包括经济补偿,筛选程序,时间承诺和粪便捐赠物流。 Logistic回归和线性回归模型估计了研究变量与自我评估的捐赠粪便意愿的关联。 802位受访者填写了我们的问卷:387(48.3%)年龄21-30岁,573(71.4%)女性,323(40%)卫生保健工作者。居住国家,年龄和职业与捐赠粪便的意愿无关。增加捐赠意愿的因素有:已经有献血者(OR 1.64),男性,无私,经济利益,了解FMT如何帮助患者(OR 1.32)以及对FMT的积极态度(OR 1.39)。降低捐赠意愿的因素有:粪便收集不愉快(OR 0.92),侵入性筛查过程(OR 0.92),粪便捐赠频率较高,对粪便的社会认知不良以及收集/运输粪便的后勤性。我们得出以下结论:1)献血者和男性更愿意考虑大便捐赠; 2)利他主义,经济补偿和积极反馈是动机; (3)筛查过程,捐赠频率高,收集/运输粪便的后勤,缺乏公众意识和负面的社会认知是威慑力。考虑这些变量可以使捐助者的招募和保留最大化。

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