pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics

摘要

Schematic representation of preparation of Dox-TPP loaded ATRAM-conjugated BSA-PLGA nanoparticles. , Transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM) images of PLGA ( ) and BSA-PLGA ( ) NPs. Scale bar = 50 nm. , Size analysis ( ) and zeta potential measurements ( ) for PLGA and BSA-PLGA NPs in 10 mM phosphate buffer at pH 7.4. , Colloidal stability analysis for BSA-PLGA NPs in 10 mM phosphate buffer at pH 7.4 ( ) and cell culture medium containing 10% fetal bovine serum (FBS) ( ). Inset: images of higher concentrations of nanoparticles dispersed in buffer ( ) and serum ( ) solutions to show the colloidal dispersity after 72 h.