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Primary orthologs from local sequence context

机译:来自局部序列上下文的主要直系同源物

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摘要

Emergence of homology classes distinguished by chronology of duplication and speciation events. : An creates as a daughter copy of in the ancestor’s genome. Then as the ancestor diverges into two offspring, and , and are inherited by both the offspring’s genomes. : of the ancestor’s genome is inherited by both the offspring’s genomes and , then in the genome of , a creates as a daughter copy of . : similar to subfigure ( ), only recent duplications in both genome and genome create and as daughter copies of and respectively. - : exhibit exactly the same evolutionary histories as subfigures ( )-( ) in gene trees. Dashed rectangles indicate genomes of different species. Solid edges (inherited branches) indicate evolutionary paths along which “inheritance between successive generations” applies. Dashed edges (derived branches) indicate creation of new duplicates. In this context, . Primary orthologs are conjectured to conserve their ancestral genomic positions, and to undergo constrained evolution. This figure can be compared with the figures in the Ensembl documentation page for “homology types” [ ], and Fig. 1 in [ ], whose “divergent edges” correspond to our “derived branches.”
机译:同源类的出现以重复和物种形成事件的时间顺序来区分。 :在祖先的基因组中将其作为子代副本创建。然后,祖先分为两个后代和,并被两个后代的基因组遗传。的祖先的基因组:既由后代的基因组继承,又在后代的基因组中作为的子代复制。 :类似于子图(),只有基因组和基因组中最近的重复都形成,并分别作为和的子代。 -:与基因树中的子图()-()具有完全相同的进化历史。虚线矩形表示不同物种的基因组。实线(继承的分支)表示“连续世代之间的继承”适用的进化路径。虚线边缘(派生的分支)表示创建了新的重复项。在这种情况下,。推测原代直系同源物可保留其祖先的基因组位置,并进行有限的进化。可以将此图与Ensembl文档页面中的“同源性类型” []和[]中的图1进行比较,图1中的“发散边”对应于我们的“派生分支”。

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