Origins and characterization of variants shared between databases of somatic and germline human mutations

摘要

Similarities in the distribution of somatic and germline variants. Histogram of Forbes coefficients across somatic samples. Virtually all somatic samples in TCGA have several-fold more variants shared with the germline database than expected by independence. Mutation rates across nucleotide contexts are correlated between the somatic and germline settings. The set of all heptamers has been split by GC content and color-coded by alternate allele to show correlation structure. Heptamers involving a CpG- > T mutation are omitted from this plot for better visualization of all other heptamers