methCancer-gen: a DNA methylome dataset generator for user-specified cancer type based on conditional variational autoencoder

摘要

DNA methylation is one of the epigenetic mechanisms, playing a critical role in various biological processes, such as gene regulation, cell differentiation, and suppression of transposable elements [ – ]. Recent studies have reported that diverse types of neoplasia and cancer are related to changes in DNA methylation [ ] and abnormal DNA methyl patterns are considered one of the biomarkers for diagnosing cancer [ , ]. In addition, the tissue-specific DNA methylation patterns determine the origin of the cancer [ ].