Intrinsic limitations in mainstream methods of identifying network motifs in biology

摘要

Examples of network motif distributions. Three examples of classes of synthetic networks and corresponding motifs that exhibit non-normal asymptotic frequency distributions. Top row: An illustrative network from each class. Middle row: A motif candidate. Bottom row: The form of the frequency distribution of the given motif candidate, calculated for networks drawn from the corresponding class. For full details see SI .2 for discussion of the Poisson distribution example, .3 for discussion of the binomial distribution example, and .4 for discussion of the multimodal example