Maternal and Early Postnatal Diet Supplemented with Conjugated Linoleic Acid Isomers Affect Lipid Profile in Hearts of Offspring Rats with Mammary Tumors

摘要

Proper feeding during pregnancy and breastfeeding plays an important role in ensuring the health of offspring in childhood as well as in adulthood. The idea of the “developmental origin of health and disease” (DOHaD) assumes that stimuli acting during fetal life cause long-term developmental and physiological changes in the main organs and influence the risk of many diseases. Our research, connected with DOHaD, made an attempt to evaluate the impact of the diet modification of mothers through the addition of conjugated linoleic acid isomers (CLA) on the lipid profile, fatty acid profile and the oxidative stress in the hearts of offspring with breast cancer. Earlier studies utilizing CLA in DOHaD concerned their impact on reducing the incidence of cancer. Considering reports on the co-occurrence of cardiovascular diseases (CVD) in oncological patients as a result of tumor development and also after chemotherapy and radiotherapy, further research is needed to assess the potential protective effect of CLA isomers in CVD. For this purpose, the content of selected CVD biomarkers was determined using modern analytical techniques. Our research has tried to explain the physiological role of CLA and its mechanism of action in the context of maintaining good health and in the prevention of non-communicable diseases.