Shape Differences in the Corpus Callosum in First-Episode Schizophrenia and First-Episode Psychotic Affective Disorder

摘要

ObjectiveThe corpus callosum, the largest white matter tract in the brain, is a midline structure associated with the formation of the hippocampus, septum pellucidum, and cingulate cortex, which have been implicated in the pathogenesis of schizophrenia. Corpus callosum shape deformation, therefore, may reflect a midline neurodevelopmental abnormality.