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Tissue strain amplification at the osteocyte lacuna: A microstructural finite element analysis

机译:骨细胞腔的组织应变扩增:微观结构有限元分析

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摘要

A parametric finite element model of an osteocyte lacuna was developed to predict the microstructural response of the lacuna to imposed macroscopic strains. The model is composed of an osteocyte lacuna, a region of perilacunar tissue, canaliculi, and the surrounding bone tissue. A total of 45 different simulations were modeled with varying canalicular diameters, perilacunar tissue material moduli, and perilacunar tissue thicknesses. Maximum strain increased with a decrease in perilacunar tissue modulus and decreased with an increase in perilacunar tissue modulus, regardless of the thickness of the perilacunar region. An increase in the predicted maximum strain was observed with an increase in canalicular diameter from 0.362 to 0.421 μm. In response to the macroscopic application of strain, canalicular diameters increased 0.8% to over 1.0% depending on the perilacunar tissue modulus. Strain magnification factors of over 3 were predicted. However, varying the size of the perilacunar tissue region had no effect on the predicted perilacunar tissue strain. These results indicate that the application of average macroscopic strains similar to strain levels measured in vivo can result in significantly greater perilacunar tissue strains and canaliculi deformations. A decrease in the perilacunar tissue modulus amplifies the perilacunar tissue strain and canaliculi deformation while an increase in the local perilacunar tissue modulus attenuates this effect.
机译:建立了骨细胞腔的参数有限元模型,以预测腔对施加的宏观应变的微观结构响应。该模型由骨细胞腔,腔周围组织,小管和周围的骨组织组成。共有45个不同的模拟模型,这些模型具有不同的小管直径,腔周围组织材料模量和腔周围组织厚度。最大应变随着腔周围组织模量的减小而增加,并且随着腔周围组织模量的增加而减小,而与腔周围区域的厚度无关。随着管径从0.362微米增加到0.421微米,观察到最大预测应变的增加。响应于应变的宏观应用,根管周围的组织模量,小管直径增加了0.8%,超过了1.0%。预计应变放大系数超过3。但是,改变腔周围组织区域的大小对预测的腔周围组织应变没有影响。这些结果表明,应用类似于体内测得的应变水平的平均宏观应变可以导致明显更大的腔周围组织应变和小管变形。腔周围组织模量的减少会放大腔周围组织的应变和小管变形,而局部腔周围组织模量的增加会减弱这种作用。

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