Abrogation of Estrogen Receptor Signaling Augments Cytotoxicity of Anticancer Drugs on CaSki Cervical Cancer Cells

摘要

BackgroundWe have reported that a gene therapy approach, using a dominant-negative estrogen receptor blocker (DN) gene, can cause cell death in cervical cancer cells in vitro. We investigated the mechanisms for enhanced cell killing when DN was combined with cisplatin (CP) and paclitaxel (TX).