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Combination Immunotherapy for Tumors via Sequential Intratumoral Injections of Oncolytic Herpes Simplex Virus 1 and Immature Dendritic Cells

机译：通过肿瘤内注射溶瘤性单纯疱疹病毒1和未成熟树突状细胞的联合免疫疗法治疗肿瘤。

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PurposeOncolytic herpes simplex virus 1 (oHSV) vectors treat tumors in preclinical models and have been used safely in phase I clinical trials for patients with cancer. Infection of tumors with oHSV also induces specific antitumor immunity. We investigated whether this immunotherapeutic effect is enhanced by combining oHSV infection with intratumoral administration of immature myeloid dendritic cells (iDC).

机译：目的溶瘤性单纯疱疹病毒1（oHSV）载体可在临床前模型中治疗肿瘤，并已在癌症患者的I期临床试验中安全使用。 oHSV感染肿瘤也可诱导特异性抗肿瘤免疫。我们研究了通过将oHSV感染与未成熟髓样树突状细胞（iDC）的肿瘤内给药相结合是否可以增强这种免疫治疗效果。

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期刊名称 other
作者
Christopher J. Farrell; Cecile Zaupa; Zachary Barnard; Jason Maley; Robert L. Martuza; Samuel D. Rabkin; William T. Curry Jr.;
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年(卷),期 -1(14),23
年度 -1
页码 7711–7716
总页数 13
原文格式 PDF
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专利

1. Combination immunotherapy for tumors via sequential intratumoral injections of oncolytic herpes simplex virus 1 and immature dendritic cells. [J] . Farrell CJ, Zaupa C, Barnard Z, Clinical cancer research: an official journal of the American Association for Cancer Research . 2008,第23期

机译：通过连续溶瘤性单纯疱疹病毒1和未成熟树突状细胞瘤内注射对肿瘤进行联合免疫治疗。
2. Combination of the tumor angiogenesis inhibitor bevacizumab and intratumoral oncolytic herpes virus injections as a treatment strategy for human gastric cancers [J] . DeguchiT., ShikanoT., KasuyaH., Hepato-gastroenterology. . 2012,第118期

机译：肿瘤血管生成抑制剂贝伐单抗和肿瘤内溶瘤性疱疹病毒注射剂的结合作为人类胃癌的治疗策略
3. Widespread intratumoral virus distribution with fractionated injection enables local control of large human rhabdomyosarcoma xenografts by oncolytic herpes simplex viruses [J] . Mark A Currier, Lisa C Adams, Yonatan Y Mahller, Cancer gene therapy . 2005,第4期

机译：分次注射的广泛肿瘤内病毒分布使得溶瘤性单纯疱疹病毒能够局部控制大型人横纹肌肉瘤异种移植
4. Vectorization in an Oncolytic Vaccinia Virus of Antibodies Against Programmed Cell Death -1 (PD-1) Allows Their Intratumoral Delivery and an Improved Tumor-Growth Inhibition [C] . Jean-Baptiste March, Patricia Kleinpeter, Laetitia Fend, Protein Engineering Summit. . 2018

机译：矢量化在抗体抗体的抗体疫苗病毒中，针对编程的细胞死亡-1（PD-1）允许其肿瘤内递送和改善的肿瘤生长抑制
5. The role of dendritic cells in the cornea in the adaptive immune response following Herpes Simplex Virus-1 ocular infection. [D] . Buela, Kristine-Ann. 2015

机译：单纯疱疹病毒1眼感染后，树突状细胞在角膜中的适应性免疫反应中的作用。
6. Inhibition of colorectal cancer liver metastasis in BALB/c mice following intratumoral injection of oncolytic herpes simplex virus type 2 for the induction of specific antitumor immunity [O] . Wen Zhang, Feifei Wang, Xiao Hu, -1

机译：肿瘤内注射溶瘤性单纯疱疹病毒2型诱导特异性抗肿瘤免疫后抑制BALB / c小鼠结直肠癌肝转移
7. Inhibition of colorectal cancer liver metastasis in BALB/c mice following intratumoral injection of oncolytic herpes simplex virus type 2 for the induction of specific antitumor immunity [O] . Wen Zhang, Feifei Wang, Xiao Hu, 2018

机译：抑制在腹腔内注射葡萄糖疱疹病毒型2型腹腔病毒型2后的Balb / C小鼠中的结肠直肠癌肝转移诱导特异性抗肿瘤免疫力

Combination Immunotherapy for Tumors via Sequential Intratumoral Injections of Oncolytic Herpes Simplex Virus 1 and Immature Dendritic Cells

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