Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Dodonaea viscosa led to the isolation of two new antiproliferative oleanane-type triterpenoid saponins, dodoneasides A and B (>1 and >2). The structures of these two new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds >1 and >2 showed antiproliferative activity against the A2780 human ovarian cancer cell line with IC50 values of 0.79 and 0.70 μM, respectively.
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