Targeting of bone-derived insulin-like growth factor-2 by a human neutralizing antibody suppresses the growth of prostate cancer cells in a human bone environment

摘要

PurposeAdvanced prostate cancer frequently involves the bone, where the insulin-like growth factor (IGF)-2 is abundant. However, the importance of IGF-2 in bone metastasis from prostate cancer is uncertain. The present study was aimed at examining the therapeutic importance of targeting IGF-2 in bone metastases from prostate cancer.