A β-Carboline Alkaloid from the Papua New Guinea Marine Sponge Hyrtios reticulatus

摘要

A new 1-imidazoyl-3-carboxy-6-hydroxy-β-carboline alkaloid, named hyrtiocarboline (>1), was isolated from a Papua New Guinea marine sponge Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including ¹H-¹⁵N HMBC NMR experiments that provided complementary ¹⁵N chemical shift information in support of the structure. This compound showed selective anti-proliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.