Molecular epidemiological analysis of mitochondrial DNA12SrRNA A1555G GJB2 and SLC26A4 mutations in sporadic outpatients with nonsyndromic sensorineural hearing loss in China

摘要

ConclusionGJB2 mutation was frequent in sporadic outpatients and its mutation frequency was significant higher in the prelingual group than in the postlingual group, whereas the mutation of mtDNA A1555G and SLC26A4 was very rare in Chinese sporadic outpatients with nonsyndromic sensorineural hearing loss (NSHL). Standard and comprehensive inclusion and grouping criteria are necessary for epidemiological studies of deafness-related gene mutations.