The Mu Opioid Receptor is Not Involved in Ethanol Stimulated Dopamine Release in the Ventral Striatum of C57BL/6J Mice

摘要

BackgroundThe mu opioid receptor (MOR) has previously been found to regulate ethanol-stimulated dopamine release under some, but not all, conditions. A difference in ethanol-evoked dopamine release between male and female mixed background C57BL/6J-129SvEv mice led to questions about its ubiquitous role in these effects of ethanol. Using congenic C57BL/6J MOR knockout (KO) mice and C57BL/6J mice pretreated with an irreversible MOR antagonist, we investigated the function of this receptor in ethanol stimulated dopamine release