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Ranolazine Decreases Mechanosensitivity of the Voltage-Gated Sodium Ion Channel NaV1.5: A Novel Mechanism of Drug Action

机译：Ranolazine降低了电压门控钠离子通道Nav1.5的机械敏感性：一种新的药物作用机制

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摘要

BackgroundNaV1.5 is a mechanosensitive voltage gated sodium-selective ion channel responsible for the depolarizing current and maintenance of the action potential plateau in the heart. Ranolazine is a NaV1.5 antagonist with anti-anginal and anti-arrhythmic properties.

机译：BackgroundNav1.5是机械敏感电压门控钠选择性离子通道，负责心脏中动作潜在高原的去极化电流和维护。 Ranolazine是具有抗角友和抗心律失常性质的NAV1.5拮抗剂。

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期刊名称 other
作者
Arthur Beyder; Peter R. Strege; Santiago Reyes; Cheryl E. Bernard; Andre Terzic; Jonathan Makielski; Michael J. Ackerman; Gianrico Farrugia;
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作者单位

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年(卷),期 -1(125),22
年度 -1
页码 2698–2706
总页数 20
原文格式 PDF
正文语种
中图分类
关键词
drugs electrophysiology ion channels mechanics myocytes;

机译：药物;电生理;离子通道;力学;肌细胞;

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专利

1. Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel NaV1.5: A novel mechanism of drug action [J] . BeyderA., StregeP.R., ReyesS., Circulation: An Official Journal of the American Heart Association . 2012,第22期

机译：雷诺嗪降低电压门控钠离子通道NaV1.5的机械敏感性：药物作用的新机制
2. Cardiac sodium channel nav1.5 mechanosensitivity is inhibited by ranolazine [J] . AbrielH. Circulation: An Official Journal of the American Heart Association . 2012,第22期

机译：雷诺嗪抑制心脏钠通道nav1.5机械敏感性
3. Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells [J] . Leila Neshatian, Peter R. Strege, Poong-Lyul Rhee, American Journal of Physiology . 2015,第3aPta1期

机译：Ranolazine抑制人结肠圆形平滑肌细胞中的电压门控机械敏感钠通道
4. Single-channel properties of voltage-gated potassium and sodium channels [C] . Ozturk, E., Ozer, . 2005

机译：电压门控钾钠通道的单通道特性
5. Voltage-gated sodium channel isoform expression in the mouse main olfactory epithelium: A neuronal role for the cardiac isoform, Nav1.5 [D] . Frenz, Christopher T. 2009

机译：小鼠主要嗅觉上皮中的电压门控钠通道亚型表达：心脏亚型，Nav1.5的神经元作用。
6. SCN5A mutation G615E results in NaV1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity [O] . Peter R. Strege, Arnaldo Mercado-Perez, Amelia Mazzone, 2015

机译：SCN5A突变G615E导致NaV1.5电压门控钠通道具有正常的电压依赖性功能，但机械敏感性降低
7. Cardiac Sodium Channel Nav1.5 Mechanosensitivity is Inhibited by Ranolazine [O] . Abriel, Hugues 2012

机译：雷诺嗪抑制心脏钠通道Nav1.5机械敏感性

Ranolazine Decreases Mechanosensitivity of the Voltage-Gated Sodium Ion Channel NaV1.5: A Novel Mechanism of Drug Action

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