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Murine toxicology and pharmacokinetics evaluation of Retinoic Acid Metabolism Blocking Agent (RAMBA) VN/12-1

机译：视黄酸代谢阻断剂（RAMBA）VN / 12-1的鼠毒理学和药代动力学评估

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PurposeNovel retinoic acid metabolism blocking agent (RAMBA), VN/12-1, is a highly potent anti-cancer agent which induces autophagy. Its combination with autophagy inhibitor chloroquine (CHL) has been shown to synergistically enhance apoptosis in breast cancer cells. The purpose of this study was to determine the toxicity and pharmacokinetic profile of VN/12-1 and its combination with CHL.

机译：Purpospovel视黄酸代谢阻断剂（RAMBA），VN / 12-1是一种诱导自噬的高效抗癌剂。其与自噬抑制剂氯喹（CHL）的组合已被证明在乳腺癌细胞中协同增强凋亡。本研究的目的是确定VN / 12-1的毒性和药代动力学谱及其与CHL的组合。

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期刊名称 other
作者
Abhijit M. Godbole; Puranik Purushottamachar; Marlena S. Martin; Vincent C. O. Njar;
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作者单位

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年(卷),期 -1(70),2
年度 -1
页码 339–344
总页数 9
原文格式 PDF
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关键词
VN/12-1 toxicology pharmacokinetics chloroquine RAMBAs;

机译：VN / 12-1;毒理学;药代动力学;氯喹;RAMBA;

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专利

1. Murine toxicology and pharmacokinetics evaluation of retinoic acid metabolism blocking agent (RAMBA), VN/12-1 [J] . GodboleA.M., PurushottamacharP., MartinM.S., Cancer chemotherapy and pharmacology. . 2012,第2期

机译：视黄酸代谢阻断剂（RAMBA）VN / 12-1的小鼠毒理学和药代动力学评估
2. Murine toxicology and pharmacokinetics evaluation of retinoic acid metabolism blocking agent (RAMBA), VN/12-1 [J] . Abhijit M. Godbole, Puranik Purushottamachar, Marlena S. Martin, Cancer Chemotherapy and Pharmacology . 2012,第2期

机译：维甲酸代谢阻断剂（RAMBA），VN / 12-1的小鼠毒理学和药代动力学评估
3. Murine toxicology and pharmacokinetics of novel retinoic acid metabolism blocking agents [J] . Jyoti B. Patel, Aakanksha Khandelwal, Pankaj Chopra, Cancer Chemotherapy and Pharmacology . 2007,第6期

机译：新型维甲酸代谢阻断剂的小鼠毒理学和药代动力学
4. Characterization of aerosol exposure, metabolism and pharmacokinetics for toxicological assessment using in vitro organotypicalairway models [C] . A. Knorr, Q. Dutertre, M. Rhouma, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：体外有机型机制毒理学评估的气雾暴露，代谢和药代动力学的特征
5. Mechanisms of Action and Efficacy Modulation of Novel Retinoic Acid Metabolism Blocking Agent (RAMBA) VN/12-1 in Estrogen Receptor-α Negative Breast Cancer Model Systems: Targeting Autophagy [D] . Godbole, Abhijit Moreshwar 2011

机译：新型视黄酸代谢阻断剂（RAMBA）VN / 12-1在雌激素受体-α阴性乳腺癌模型系统中的作用和功效调节机制：靶向自噬
6. First Chemical Feature Based Pharmacophore Modeling of Potent Retinoidal Retinoic Acid Metabolism Blocking Agents (RAMBAs): Identification of Novel RAMBA Scaffolds [O] . Puranik Purushottamachar, Jyoti B. Patel, Lalji K Gediya, -1

机译：基于第一化学特征的有效视网膜视黄酸代谢阻断剂的药物造型造型（rambas）：鉴定新颖的Ramba支架
7. Murine toxicology and pharmacokinetics evaluation of retinoic acid metabolism blocking agent (RAMBA), VN/12-1 [O] . Abhijit M. Godbole, Puranik Purushottamachar, Marlena S. Martin, 2012

机译：视黄酸代谢阻断剂（RAMBA），VN / 12-1的鼠毒理学和药代动力学评估

Murine toxicology and pharmacokinetics evaluation of Retinoic Acid Metabolism Blocking Agent (RAMBA) VN/12-1

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