Assessment of Bias in Experimentally Measured Diffusion Tensor Imaging Parameters Using SIMEX

摘要

Diffusion tensor imaging (DTI) enables in vivo investigation of tissue cytoarchitecture through parameter contrasts sensitive to water diffusion barriers at the micrometer level. Parameters are derived through an estimation process which is susceptible to noise and artifacts. Estimated parameters (e.g., fractional anisotropy) exhibit both variability and bias relative to the true parameter value estimated from a hypothetical noise-free acquisition. Herein, we present the use of the SIMulation and EXtrapolation (SIMEX) approach for post hoc assessment of bias in a massively-univariate imaging setting and evaluate the potential of a SIMEX-based bias correction. Using simulated data with known truth models, spatially varying FA bias error maps are evaluated on two independent and highly differentiated case studies. The stability of SIMEX and its distributional properties are further evaluated on 42 empirical DTI datasets. Using gradient sub-sampling, an empirical experiment with a known true outcome is designed and SIMEX performance is compared to the original estimator. With this approach, we find SIMEX bias estimates to be highly accurate offering significant reductions in parameter bias for individual datasets and greater accuracy in averaged population-based estimates.