A Phase II Clinical Trial of Sequential Neoadjuvant Chemotherapy with Ifosfamide Doxorubicin and Gemcitabine followed by Cisplatin Gemcitabine and Ifosfamide in Locally Advanced Urothelial Cancer: Final Results

摘要

IntroductionNeoadjuvant chemotherapy improves survival in high-risk urothelial cancer. However, the lack of curative alternatives to cisplatin-based chemotherapy is limiting for patients with neuropathy or hearing loss. Sequential chemotherapy is also not well studied in the neoadjuvant setting. We explored sequential neoadjuvant ifosfamide-based chemotherapy in a patient cohort at “high-risk” of non-curative cystectomy.